Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Headache
ADR ID BADD_A01965
ADR Hierarchy
17      Nervous system disorders
17.14      Headaches
17.14.01      Headaches NEC
17.14.01.001      Headache
Description A disorder characterized by a sensation of marked discomfort in various parts of the head, not confined to the area of distribution of any nerve. [CTCAE] The symptom of PAIN in the cranial region. It may be an isolated benign occurrence or manifestation of a wide variety of HEADACHE DISORDERS. [MeSH]
MedDRA Code 10019211
MeSH ID D006261; D006261; D006261; D006261; D020773; D006261; D051270
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Cephalalgia | Cephalalgia or cephalgia | Cephalgia | Forehead headache | Head pain | Head throbbing | Headache | Headache (except migraine) aggravated | Headache discomfort | Headache dull | Headache fullness | Headache NOS | Headache NOS aggravated | Headache occurring | Headache temporal | Headache transient | Hemicephalgia | Hemicrania | Nocturnal headache | Pain head | Pounding in head | Temporal headache | Headache aggravated | Frontal headache | Occipital headache | Parietal headache | Headache unilateral | Drug-induced headache | Frequent headaches | Chronic headaches | Headache (excl migraine) aggravated | Throbbing headache | Intermittent headache | Retroauricular pain | Headache recurrent | Hemicephalalgia | Ice pick headache | Headaches | Head Pain | Head Pains | Pain, Head | Pains, Head | Cephalodynia | Cephalodynias | Cranial Pain | Cranial Pains | Pain, Cranial | Pains, Cranial | Cephalalgias | Cephalgias | Generalized Headache | Generalized Headaches | Headache, Generalized | Headaches, Generalized | Ocular Headache | Headache, Ocular | Headaches, Ocular | Ocular Headaches | Orthostatic Headache | Headache, Orthostatic | Headaches, Orthostatic | Orthostatic Headaches | Vertex Headache | Headache, Vertex | Headaches, Vertex | Vertex Headaches | Retro-Ocular Headache | Headache, Retro-Ocular | Headaches, Retro-Ocular | Retro Ocular Headache | Retro-Ocular Headaches | Sharp Headache | Headache, Sharp | Headaches, Sharp | Sharp Headaches | Throbbing Headache | Headache, Throbbing | Headaches, Throbbing | Throbbing Headaches | Unilateral Headache | Headache, Unilateral | Headaches, Unilateral | Unilateral Headaches | Bilateral Headache | Bilateral Headaches | Headache, Bilateral | Headaches, Bilateral | Periorbital Headache | Headache, Periorbital | Headaches, Periorbital | Periorbital Headaches
ADR Related Proteins
Protein Name UniProt AC TTD Target ID
Cytochrome P450 2D6P10635T57392
Cytochrome P450 3A4P08684T37848
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00132Amphotericin b--
BADD_D00136Amprenavir--
BADD_D00137Amsacrine--
BADD_D00138Amyl nitrite--
BADD_D00139Anagrelide0.000799%
BADD_D00140Anagrelide hydrochloride--
BADD_D00141Anakinra--
BADD_D00142Anastrozole0.015084%
BADD_D00143Anidulafungin--
BADD_D00144Antagon--
BADD_D00146Anti-thymocyte globulin (rabbit)--
BADD_D00147Antihemophilic factor (recombinant)--
BADD_D00151Apixaban--
BADD_D00152Apomorphine--
BADD_D00153Apomorphine hydrochloride--
BADD_D00154Apraclonidine--
BADD_D00155Apraclonidine hydrochloride--
BADD_D00156Apremilast3.552113%
BADD_D00157Aprepitant0.000561%
BADD_D00159Arformoterol--
BADD_D00160Arformoterol tartrate--
BADD_D00161Argatroban--
BADD_D00162Arginine--
BADD_D00163Arginine hydrochloride--
BADD_D00164Argipressin--
BADD_D00165Aripiprazole--
BADD_D00166Aripiprazole lauroxil--
BADD_D00167Armodafinil0.029656%
BADD_D00168Arsenic--
BADD_D00169Arsenic trioxide0.001598%
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